LA Memorial Coliseum, September 16, 2025
News Summary
The Michigan State Spartans are set to face the USC Trojans in a pivotal Big Ten opener at the LA Memorial Coliseum. With both teams entering the game with perfect 3-0 records, the matchup is charged with historical significance as the Spartans have never won against USC on the road. Led by head coach Jonathan Smith, Michigan State aims to overcome injuries and tackle their defensive struggles against a formidable Trojans squad known for its top-ranked offense. The game promises to be a crucial test for both teams.
Los Angeles – The Michigan State Spartans are set to take on the USC Trojans this Saturday, September 20, in a highly anticipated Big Ten opener at the LA Memorial Coliseum. This matchup is significant as it marks the first trip west for the Spartans to compete against their new Big Ten rivals and it represents the ninth meeting between the two teams, who are currently tied at 4-4.
The kickoff for the game is scheduled for 11 PM Eastern time, making it the latest for an MSU game since their encounter with Arizona State in 2018. Historically, Michigan State has never defeated USC on the road, adding extra pressure to this encounter for the Spartans.
Michigan State will be led by head coach Jonathan Smith, facing USC’s head coach Lincoln Riley, who boasts an impressive career record of 84-24. Riley previously guided the Oklahoma Sooners to four Big 12 Championships and three College Football Playoff appearances before taking the helm at USC.
USC has shown a notable decline in performance over the past three seasons, finishing with records of 11-3 in 2022, 8-5 in 2023, and 7-6 in 2024. However, the Trojans have found success in the current season, entering the game with a perfect 3-0 record. They are recognized for their high-powered offense, ranked No. 1 in total offense and No. 2 nationally in scoring offense.
In contrast, the Spartans have struggled defensively in recent games, making this matchup a crucial test for them. As the game approaches, Michigan State is currently viewed as a 13-point underdog according to the betting odds, with an over-under set at 58 points, which suggests a projected score favoring USC at 36-23.
Both teams begin this contest with identical records of 3-0. However, Michigan State faces challenges with injuries to key players, including wide receiver Nick Marsh and running back Makhi Frazier. The Spartans recently celebrated a 41-24 victory over Youngstown State but displayed inconsistency against their FCS opponents.
USC, on the other hand, secured a recent win against Purdue with a score of 33-17, showcasing a formidable defense alongside their offensive strength. As Michigan State seeks to enhance their standing within the competitive Big Ten environment, this game serves as an important step in addressing their vulnerabilities and building momentum.
The game will be broadcast on FOX and available for streaming on Fubo.
Key Matchup Overview
- Date: September 20
- Location: LA Memorial Coliseum
- Kickoff Time: 11 PM ET
- Series Record: Tied at 4-4
- Current Records: Both teams 3-0
- Betting Odds: MSU +13
- Over/Under: 58 points
Injury Report
- Michigan State’s Key Injuries:
- WR Nick Marsh
- RB Makhi Frazier
Upcoming Broadcast
- TV: FOX
- Streaming: Fubo
FAQ Section
What time does the Michigan State vs USC game start?
The game is scheduled to start at 11 PM Eastern time.
Where will the game be played?
The game will be played at the LA Memorial Coliseum.
How have the Spartans performed against USC historically?
The all-time series is currently tied at 4-4, with Michigan State never having defeated USC on the road.
What are the betting odds for the game?
The Spartans are 13-point underdogs against USC.
Summary Table of Game Details
| Details | Information |
|---|---|
| Date | September 20 |
| Location | LA Memorial Coliseum |
| Kickoff Time | 11 PM ET |
| Series Record | Tied 4-4 |
| Current Record | Both teams 3-0 |
| Betting Odds | MSU +13 |
| Over/Under | 58 points |
Deeper Dive: News & Info About This Topic
HERE Resources
Michigan State University Secures Victory Amidst Injury Concerns
Michigan State Spartans Win Thrilling Double Overtime Match
MSU Baseball Team Secures Spot in Big Ten Tournament
Michigan’s Liquor Sales Reach Nearly $2 Billion in 2024
Novi Wildcats Face Defeat Against Hartland Eagles in Recent Matchup
Spartans Secure First Place in Big Ten with Wisconsin Win
Michigan State Moves to First Place in Big Ten with Win Over Wisconsin
Michigan State Hockey Team Back at No. 1 in USCHO Rankings
MSU Women’s Basketball Falls to UCLA in Hard-Fought Match
Michigan Gaming Control Board Targets Unlicensed Gambling Sites
Additional Resources
- Spartans Wire: MSU Football Betting Line Against USC
- Wikipedia: United States Congress
- Detroit Free Press: MSU vs USC Football Prediction
- Google Search: Michigan State Spartans football
- 247Sports: Quick Look at Michigan State
- Google Scholar: Michigan State vs USC
- Lansing State Journal: MSU vs USC Analysis
- Encyclopedia Britannica: College Football
- On3: Nick Marsh Injury Update
- Google News: Michigan State vs USC game
Author: STAFF HERE NOVI WRITER
The NOVI STAFF WRITER represents the experienced team at HERENovi.com, your go-to source for actionable local news and information in Novi, Oakland County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as Motor City Comic Con, Michigan State Fair, and Novi Home and Garden Show. Our coverage extends to key organizations like the Novi Chamber of Commerce and Novi Community Foundation, plus leading businesses in automotive, technology, and manufacturing that power the local economy such as Gentherm, Stoneridge, and Daifuku North America. As part of the broader HERE network, including HEREDetroitMI.com, HEREGrandRapids.com, HERENorthville.com, and HEREPlymouth.com, we provide comprehensive, credible insights into Michigan's dynamic landscape.
